This is important as GH replacement is required not only for growth during childhood but also for metabolic health during adulthood ( 9). However, adherence to this regimen has been shown to be suboptimal ( 7, 8). GH treatment currently requires administration using daily subcutaneous injections ( 1, 3). The demonstrated benefits of GH therapy include improvement in body composition, surrogate markers of cardiovascular risk factors, exercise capacity, skeletal integrity and quality of life ( 1, 2, 3, 4, 5, 6). Current guidelines for the use of r-hGH in adults recommend individualized dosing based on serum IGF-I levels and the absence of adverse events (AEs) ( 1, 2, 3).
The primary goal of growth hormone (GH) replacement in adults is to correct the abnormalities associated with GH deficiency (GHD).
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